Physorg (Free subscription) | 16 hours ago
(PhysOrg.com) -- An anti-convulsant drug commonly used to treat epilepsy reduces cysts in mice that are associated with polycystic kidney disease (PKD), a difficult to treat ailment that afflicts 600,000 people in the United States, Yale University researchers report.
Team Côte d'Azur News (Free subscription) | 11/17/2009
Work carried out within the IPMC*-CNRS has uncovered the molecular and cellular mechanisms that cause this frequent hereditary disease.
PLoS ONE (Free subscription) | 11/14/2009
Our recognition of the mitochondria as being important sites of fatty acid biosynthesis is continuously unfolding, especially in light of new data becoming available on compromised fatty acid synthase type 2 (FASII) in mammals. For example, perturbed regulation of murine 17β-HSD8 encoding a component of the mitochondrial FASII enzyme 3-oxoacyl-thioester reductase is implicated in polycystic kidney...
kansascity.com (Free subscription) | 11/10/2009
LAWRENCE | The Kansas Bioscience Authority has given almost $3 million to the University of Kansas in an effort to recruit researchers to the state. The KBA board of directors agreed Monday to spend $2.49 million over five years to direct and expand the university’s laboratory for macromolecular and vaccine stabilization. Another $500,000 would be spent over three years for a top researcher...
Medical News Today (Free subscription) | 11/06/2009
What is the role of proteins called polycystins in patients with polycystic kidney disease? A team of researchers from CNRS and INSERM, led by Eric Honore from the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC, Universite de Nice Sophia Antipolis/CNRS) has elucidated the molecular and cellular mechanisms linked to polycystin malfunctions that cause this common hereditary disease....
Science Daily (Free subscription) | 11/06/2009
What is the role of proteins called polycystins in patients with polycystic kidney disease? Scientists have elucidated the molecular and cellular mechanisms linked to polycystin malfunctions that cause this common hereditary disease.
Physorg (Free subscription) | 11/05/2009
What is the role of proteins called polycystins in patients with polycystic kidney disease? A team of researchers from CNRS and INSERM, led by Eric Honoré from the Institut de Pharmacologie Moléculaire et Cellulaire (France) has elucidated the molecular and cellular mechanisms linked to polycystin malfunctions that cause this common hereditary disease. In a study published on October...
DB's Medical Rants (Free subscription) | 10/31/2009
The patient is a 38 year old man admitted with a bleeding ulcer. It is 3 days later, he is otherwise stable and has these labs. He has known polycystic kidney disease with an estimated GFR of 30. He weights approximately 70 kg. Electrolyte panel Na 141 Cl 116 BUN 49 K 4.8 HCO3 16 creat 2.7 Blood Sugar 90 ABG pH 7.25 pCO2 33 pO2 83 HCO3 15 So please address these questions: 1. What is the [...] Related...
DB's Medical Rants (Free subscription) | 10/28/2009
The patient is a 38 year old man admitted with a bleeding ulcer. It is 3 days later, he is otherwise stable and has these labs. He has known polycystic kidney disease with an estimated GFR of 30. He weights approximately 70 kg. Electrolyte panel Na 141 Cl 116 BUN 49 K 4.8 HCO3 16 creat 2.7 Blood Sugar 90 ABG pH 7.25 pCO2 33 pO2 83 HCO3 15 So please address these questions: 1. What is the [...] Related...
Business Wire (Free subscription) | 10/26/2009
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Napo Pharmaceuticals, Inc. has in-licensed from the University of California Regents additional small-molecule cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor technology including gastrointestinal (GI) and polycystic kidney disease (PKD) indications. PKD, a leading cause of end-stage renal disease and kidney transplants, affects approximately...
John Goodman's Health Policy Blog (Free subscription) | 10/08/2009
It’s posed by Nicholas D. Kristof in the New York Times: Mr. Waddington has polycystic kidney disease, or PKD, a genetic disorder that leads to kidney failure. First he lost one kidney, and then the other…. Doctors explained that the best match — the one least likely to be rejected — would perhaps come from Travis [...]
PLoS ONE (Free subscription) | 10/08/2009
Background The perception of sour taste in humans is incompletely understood at the receptor cell level. We report here on two patients with an acquired sour ageusia. Each patient was unresponsive to sour stimuli, but both showed normal responses to bitter, sweet, and salty stimuli. Methods and Findings Lingual fungiform papillae, containing taste cells, were obtained by biopsy from the two patients,...
Bounded Rationality (Free subscription) | 10/06/2009
A good editorial to read if you are interested in the debate regarding health care reform. If your mind is made up, or if you've allowed somebody else to make your mind up for you, you may not be interested. Nicholas Kristof of the New York Times writes in Dad's Life or Yours? You Choose. It's about a gentleman in Dallas, Mr. Waddington facing the following dilemma: Mr. Waddington has polycystic kidney...
Crooks and Liars (Free subscription) | 10/06/2009
I had to make a less compelling but similar choice several years ago, when one of my cousins, who also had PKD, asked us all to get tested for possible transplant donation. I was out of work and uninsured, and I knew if I had any complications, I couldn't afford treatment. Even though I felt really bad about it, I didn't get tested. Isn't it horrible that we're making moral decisions on such immoral...
Medindia Health News (Free subscription) | 10/03/2009
Monash University researchers have found what they call 'microscopic antennas' that play a vital role in kidney repair p
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