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Creutzfeldt-Jakob Disease


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Modified Virus Used To Treat Prion Disease In Mice

A treatment that prolongs survival in mice with prion disease has been found in research led by Dr Giovanna Mallucci at the Medical Research Council Prion Unit at UCL (University College London). Examples of prion diseases include vCJD and kuru in humans and BSE in cows. The results are published in PNAS.

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Prion Disease Transmission: Can We Apply Standard Precautions to Prevent or Reduce Risks?

By McDonnell, Gerald KEYWORDS Decontamination / Inactivation / Prion / Sterilisation Prion diseases present unique challenges to healthcare facilities, both in the care and treatment of patients.

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New Fatal CJD-Like Dementia Discovered In America

A new dementia that is distinct from but resembles known forms of CJD, Creutzfeldt-Jakob disease, has been discovered in America, affecting 16 people, 10 of whom have died after gradually losing their mental and motor functions and being unable to think, speak or move.

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Clear Differences Found Between The Structures Of Infectious And Non-Infectious Prions

Infectious proteins known as prions have been identified as the cause of "mad cow" disease (BSE). The culprits are "incorrectly folded" proteins that can "infect" healthy proteins. The molecular bases for such prion diseases are not yet fully understood.

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Tracking Prions

Infectious proteins known as prions have been identified as the cause of “mad cow” disease (BSE). The culprits are “incorrectly folded” proteins that can “infect” healthy proteins. The molecular bases for such prion diseases are not yet fully understood. Why are some proteins infectious while others are not?

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Infectious And Non-infectious Prions Have Clear Differences In Molecular Structures

Infectious proteins known as prions have been identified as the cause of “mad cow” disease (BSE). The culprits are “incorrectly folded” proteins that can “infect” healthy proteins. The molecular bases for such prion diseases are not yet fully understood. Why are some proteins infectious while others are not? Scientists examined two different forms of a prion-forming protein domain by means of NMR spectroscopy...

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Protein Fibrils as Alternative Plastics?

Amyloid deposits in tissues and organs are linked to a number of diseases, including Alzheimer`s, Parkinson`s, type II diabetes, and prion diseases such as BSE. However, amyloids are not just pathological substances; they have potential as a nanomaterials.

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Could Amyloid Deposits Have Potential As Nanomaterials?

Amyloid deposits in tissues and organs are linked to a number of diseases, including Alzheimer's, Parkinson's, type II diabetes, and prion diseases such as BSE. However, amyloids are not just pathological substances; they have potential as nanomaterials.

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Alzheimer's Disease: Finding Has Implications For Host Of Neurodegenerative Diseases

Researchers from the University of Pennsylvania School of Medicine have shown, in unprecedented detail, how a small molecule is able to selectively take apart abnormally folded protein fibers connected to Alzheimer's disease and prion diseases. The findings appeared online in the Proceedings of the National Academy of Sciences.

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How small molecule can take apart Alzheimer's disease protein fibers

Researchers from the University of Pennsylvania School of Medicine have shown, in unprecedented detail, how a small molecule is able to selectively take apart abnormally folded protein fibers connected to Alzheimer's disease and prion diseases. The findings appear online this week in the Proceedings of the National Academy of Sciences. Finding a way to dismantle misfolded proteins has implications...

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Beef Consumption Safeguards Strengthened, Says FDA

A final regulation which bans specific cattle material from all animal feed and pet foods has been issued by the Food and Drug Administration (FDA). The FDA says this final regulation protects both animals and consumers from mad cow disease (BSE - bovine spongiform encephalopathy). Dr. Bernadette Dunham, Director, Center for Veterinary Medicine, FDA, said "This FDA action serves to further protect...

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Transmitting prion diseases in milk

Scrapie can be transmitted to lambs through milk, according to new research published in the online open access journal BMC Veterinary Research. The study provides important information on the transmission of this prion-associated disease and the control of scrapie in affected flocks. Scrapie is a fatal neurodegenerative disease of sheep and goats. Clinical signs include itchiness, head tremor, wool...

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News From The American Chemical Society Feb. 27, 2008

A nano-sensor for better detection of Mad Cow Disease agentIn an advance in food safety, researchers in New York are reporting development of a nano-sized sensor that detects record low levels of the deadly prion proteins that cause Mad Cow Disease and other so-called prion diseases.

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Nano-sensor For Better Detection Of Mad Cow Disease Agent

In an advance in food safety, researchers are reporting development of a nano-sized sensor that detects record low levels of the deadly prion proteins that cause Mad Cow Disease and other so-called prion diseases. The sensor, which detects binding of prion proteins by detecting frequency changes of a micromechanical oscillator, could lead to a reliable blood test for prion diseases in both animals...